Overall, we saw a correlation between pathway activity levels (as measured by ERK phosphorylation) and roundness in mitosis, with cells with higher levels (Ras-activated MCF10A and Ras-transformed cancer cells) rounding up more at mitosis and cells with lower levels (non-transformed MCF10A and all cell types when treated with MEK or ERK inhibitors) remaining more spread. The gene discussed is MAP2K7; the disease is cancer.