However, differences in the mechanism of action of the same compound between cell lines have been described before and is a confirmation of the heterogeneity of tumour cells.22 Dasatinib‐inhibited pChk1 and increased pH2AX, markers of DNA damage, suggesting that this compound facilitates genetic instability sensitizing cancer cells to the action of PARP inhibitors. This evidence concerns the gene PARP1 and neoplasm.