NEFL and spinal muscular atrophy, type 1: Baseline values of both pNfH and NfL in the patient with SMA type 1 were much higher than those observed in healthy controls (6.874 ng/mL and >10 000 pg/mL, respectively), in accordance with existing data from the literature.7, 12 Levels of both neurofilament types showed a progressive and rapid reduction, and at 6 months from treatment start they were comparable to those of healthy individuals (data not shown).