VEGFA and hereditary hemorrhagic telangiectasia: Hence, increasing interest in the role of antibodies targeting VEGF for the treatment of severe forms of HHT has arisen, especially for those patients with iron deficiency refractory anemia (IDRA) and/or progressive hepatic disease leading to HOCF, as a bridge to LT or for cases in which LT is contraindicated or unaccepted [23].