The mechanisms by which acetylcholinesterase inhibitors promote recovery from post stroke cognitive impairment are currently not fully understood, but two mechanisms are mostly considered to be: 1) Acetylcholine acting as a cortical modulator playing a critical role in practice-related plasticity [20] and, 2) the regulation of cerebral circulation influenced by cholinergic mechanisms and acetylcholine improving regional cerebral blood flow in vascular dementia patients [17]. This evidence concerns the gene ACHE and Stroke.