Interestingly, Fbxw7 localizes to human chromosome 4q31.3, which is deleted in about 30% of human cancers and somatic mutations in Fbxw7 have been detected in tumors of diverse tissue origin, including blood, breast, bile duct, colon, endometrium, stomach, lung, bone, ovary, pancreas and prostate [83, 84]. Here, FBXW7 is linked to cancer.