Following that, genetic variants in vascular endothelial growth factor (VEGF), Rho/Rac guanine nucleotide exchange factor 18 (ARHGEF18), lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1), superoxide dismutase 2 (SOD2), and many more were identified to be associated with the susceptibility of PAH consecutively [13, 14, 16, 17]. This evidence concerns the gene ARHGEF18 and pulmonary arterial hypertension.