The effect size for any purchase among offspring to severely obese mothers with type 2 diabetes (HR, 2.25; 95% CI, 1.66-3.03) was higher than that for severely obese mothers without diabetes (HR, 1.68; 95% CI, 1.50-1.89) and was lower than that for offspring of severely obese mothers with insulin-treated pregestational diabetes (HR, 4.20; 95% CI, 2.67-6.59). Here, INS is linked to type 2 diabetes mellitus.