INS and obesity due to melanocortin 4 receptor deficiency: Severe obesity in insulin-treated pregestational diabetes was associated with offspring mood disorders (HR, 8.03; 95% CI, 3.32-19.43) and intellectual disability (HR, 3.64; 95% CI, 1.63-8.14) with large effect sizes (Figure 1B and C and Table 2), although there was no association with offspring anxiety disorders (HR, 1.05; 95% CI, 0.26-4.18) (Table 2).