We predict that differentiation human periderm is similarly controlled as genes encoding orthologs of these proteins are implicated in risk for orofacial clefting (e.g., GRHL3, KLF4, and KRT18) (Leslie et al., 2017; Liu et al., 2016; Leslie et al., 2016; Peyrard-Janvid et al., 2014). This evidence concerns the gene KRT18 and orofacial cleft.