HMGA2 and neoplasm: As an oncogenic architectural transcription factor, HMGA2 can interact with the AT‐rich regions of DNA via its “AT‐hooks” domain.18 High HMGA2 is frequently observed in tumor tissues but nearly disappears in normal tissues.18, 19 HMGA2 augmentation is closely correlated with poor survival of breast, colorectal or lung cancer patients.20, 21, 22 The evidence proves that oncogenic HMGA2 participates in DNA damage repair, stem cell self‐renewal, or tumor growth.23, 24, 25, 26 HMGA2 is considered to promote tumor development in part through its target genes.