Meanwhile, there are new trends in the treatment of liver disease which are using dual PPARα/γ or PPAR δ/γ agonists and pan agonists to enhance treatment efficacy.39, 40 Of note, synthetic dual or pan PPAR agonists were discontinued due to adverse events.41 It has been showed that resveratrol,42 carvacrol,43 osthole,44 dark tea extracts,45 isoprenols,46 pseudolaric acid B,47 mulberry leaf water extract, Korean red ginseng, banaba leaf water extract,48 and cannabinoids49 activate two or three isotypes of PPARs, and can therefore be used for regulate metabolism. The gene discussed is PPARA; the disease is liver disorder.