Previous studies16, 31, 32, 33, 34, 35, 36 indicated that TGFβ1, SHH, EGFR, and LEF‐1 may be transferred or modulated by exosomes and those proteins may play a part in the tumor development, so we tested the expression of those proteins in lysis solutions of NFs and CAFs. This evidence concerns the gene SHH and neoplasm.