PTCH1 and Insulin resistance: Qi et al found that adipocyte‐derived exosomes containing SHH lead to the M1 polarization of macrophages, which promotes insulin resistance via the Ptch/PI3K pathway in adipocytes.32 Neha revealed that vertebrate Hedgehog is secreted on two types of extracellular vesicles with different functions.31 Herein, we identified that the expression of SHH elevated in cell lysis solution, CM and exosomes of CAFs compared to the NFs.