SHH and cancer: As previously reported, abnormal activation of Hedgehog signaling pathway was positively correlated with the clinical manifestations, lymph node metastasis, and overall survival rate of many cancers.46, 47 Strikingly, SHH signaling pathway is not merely a cell‐intrinsic pathway that regulates the activity of the cancer cell, but is also modulated by the extrinsic microenvironment.48, 49 Recent studies showed that exosomes can act as natural vehicles for delivering protein of SHH.