KRAS and cervical squamous intraepithelial neoplasia: Supporting this idea, we found that upon doxycycline withdrawal, higher percentage of chromosomically unstable KM tumours were able to resist and continue growing compared to K tumours, indicating that the presence of CIN during primary tumour development increases the chance to develop therapy resistance in a model of Kras‐driven breast cancer (Rowald et al, 2016).