Studies have reported that H3K9me3 modification in the promoter region of the gene can affect the transcriptional activity of some genes.75, 76, 77 Our results also confirmed that miR‐24‐2 increased the H3K9me3 loading on the oncogene pim 1 promoter region, thereby promoting the expression of Pim1, indicating that the change of H3K9me3 modification triggered by miR‐24‐2 is beneficial to the growth of cancer cells at least in hepatoma cell Hep3B. The gene discussed is PIM1; the disease is cancer.