At the molecular level, PD (6-OHDA/MPTP)- and AD (STZ/Aβ1–42)-causing neurotoxins share mitochondria as the same intracellular target of their toxicity (Walsch et al. 2011), while their targets greatly differ at the cellular membrane; PD-causing neurotoxins are both linked to DAT (Storch et al. 2004), whereas AD-causing ones are either linked to GLUT2 and/or IR (STZ) (Gai et al. 2004; Knezovic et al. 2017), or have no known preferences for membrane targets (Aβ1–42). Here, SLC6A3 is linked to Alzheimer disease.