Additionally, from that time-point onward, impaired insulin and dopaminergic signalling in the brain (and in the striatum and hippocampus in particular) have been detected both in AD and PD models (Salkovic-Petrisic et al. 2006; Lester-Coll et al. 2006; Grünblatt et al. 2007; Morris et al. 2008; Deng et al. 2009; Agrawal et al. 2010; Shonesy et al. 2012; Lee et al. 2014; Barilar et al. 2015; Knezovic et al. 2015, 2017; Hu et al. 2018; Rabie et al. 2018; Gupta et al. 2018; Wang et al. 2018a, b; Nassar et al. 2018). Here, INS is linked to Alzheimer disease.