MAPT and Parkinson disease: However, a growing body of evidence has emerged showing its co-localisation and synergistic effects with other proteins prone to pathological misfolding (e.g. Aβ and hyperphosphorylated tau protein) in neurodegenerative disorders other than PD, which finally led to a conclusion that α-Syn is more likely a non-specific bystander and a contributor to neurodegeneration in general, than a specific etiopathogenic factor of PD (Riederer et al. 2019).