AKT1 and Cognitive impairment: Recent evidence suggests that the neurotoxic properties of Aβ and related cognitive impairment are mediated by oxidative stress, neuroinflammation but also by the disturbed PI3K/AKT/GSK3 signalling pathway (Morroni et al. 2016; Schmid et al. 2017; Amin et al. 2015).