These are type I cancer (PD-L1( +) tumor cells and TIL( +); adaptive immune resistance), type II cancer (PD-L1(−) tumor cells and TIL(−); immunologic ignorance), type III cancer (PD-L1( +) tumor cells and TIL(−); intrinsic induction), and type IV cancer (PD-L1(−) tumor cells and TIL( +); tolerance). This evidence concerns the gene CD274 and neoplasm.