Our primary findings were as follows: (1) We identified 2953 proteins, including 74 significantly upregulated DEPs and 88 significantly downregulated DEPs, between control and pulmonary hypertensive lung tissues; (2) GO analysis elucidated the top 20 terms associated with categories of biological process, cellular component, and molecular function; (3) KEGG and PPI analyses identified the top 10 signaling pathways and six hub proteins, including PRKAA1, DHPR, ACTB, desmin, ACTG1 and ITGA1. This evidence concerns the gene QDPR and pulmonary hypertension.