For example, the proteins highlighted in red boxes in Figs. 6, 7 and 8 including DHPR, ACTB, desmin, ACTG1, PRKAA1 and ITGA1, were all involved in hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and dilated cardiomyopathy (Table 2). This evidence concerns the gene ACTG1 and hypertrophic cardiomyopathy.