For example, the proteins highlighted in red boxes in Figs. 6, 7 and 8 including DHPR, ACTB, desmin, ACTG1, PRKAA1 and ITGA1, were all involved in hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and dilated cardiomyopathy (Table 2). Here, DES is linked to dilated cardiomyopathy.