IGHE and airway hyperresponsiveness: OVA-sensitized and challenged mice had significantly increased number of BALF inflammatory cell count, particularly eosinophil count (Fig. 7B), airway hyperresponsiveness (Fig. 7C), significantly elevated BALF levels of IL-4 and IL-5 (Fig. 7D,E), and elevated BALF total and OVA-specific IgE (Fig. 7F,G).