Our results in cultured renal tubular cells demonstrated that St-PGA-CL-BDMC-mediated inhibition of z-VAD/TTI-induced necroptosis, as assessed by the inhibition of cell death and MLKL phosphorylation, add a new perspective in the explanation of the lower severity of cell death observed in AKI mice treated with the St-PGA-CL-BDMC. This evidence concerns the gene MLKL and acute kidney injury.