Compared to untreated FA-AKI mice, kidneys from animals treated with St-PGA-CL-BDMC exhibited lower levels of nuclear phospho-c-JUN as assessed by Western blot (Fig. 7C,D) (Supplementary Fig. S3) and further localized in tubular cells by immunohistochemistry (Fig. 7E). The gene discussed is JUN; the disease is Friedreich ataxia.