Whereas lower levels of HO-1, Lcn2 and PCNA in a context of preserved function may reflect the milder renal injury55, the inhibition of FA-AKI-induced Fn14 expression and Klotho suppression could also contribute to the downregulation of AKI-associated inflammation, thus preventing the amplification of injury. Here, TNFRSF12A is linked to acute kidney injury.