After propensity score 1:1 matched by number of tumors, viral hepatitis status, serum levels of AFP and total bilirubin which would have impacts on adverse tumor events, patients with significant LS still had greater levels of prothrombin time, ALT,AST, APRI, white blood cell counts, but lower serum albumin and platelet counts. The gene discussed is F2; the disease is animal viral hepatitis.