FCGR1A and Miyoshi myopathy: While in solid tumors HDN could reflect the composition of immune infiltrate in tumor microenvironment without exerting immune-suppressive activity, HDN in MGUS and MM patients are immune-suppressive and share immune-suppressive features with G-MDSC, associated to increased CD64 and Arg-1, reduced phagocytosis and CD1625,34,60.