There is an emerging interest in identifying the molecular machinery involved in the IFN response in the MM microenvironment, since several cellular types show an IFNAR1 related signature in response to type 1 interferon secretion by myeloma cells72, while type 3 interferon is reduced73 due to anergic NK and T-cells61 also in the asymptomatic MGUS phase74. This evidence concerns the gene IFNA1 and Miyoshi myopathy.