Knowing, that scientific evidence proposed high resistin and IL-18 level to induce insulin resistance and promote inflammatory processes, thereby playing a central role in various metabolic, inflammatory and autoimmune diseases17,18, it was surprising, that increased resistin and IL-18 concentrations were highly correlated with the duration of a vegan diet, and in some degree, also IL-1 RA. This evidence concerns the gene IL18 and Insulin resistance.