For example, lncRNA HOTAIR increased cancer invasiveness and metastasis in an PRC2-dependent manner13; LincRNA ZEB1-AS1 is up-regulated in hepatocellular carcinoma (HCC) and promotes tumor growth and metastasis through targeting ZEB114; LncRNA HULC up-regulates HMGA2 as a microRNA sponge and promotes liver cancer growth15; LncRNA HNF1A-AS1 is upregulated in colon cancer and mediates metastatic progression in part through the miR34a/p53 signaling axis16. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.