The results showed that GPNCA was notably overexpressed in colon cancer tissues (COAD, p < 0.001; Fig. 2A), liver cancer tissue (LIHC, p < 0.001; Fig. 2B), renal clear cell cancer tissue (KIRC, p = 0.046; Fig. 2C), breast cancer tissue (BRCA, p < 0.001; Fig. 2D), prostate cancer tissue (PRAD, p < 0.001; Fig. 2E), Kidney renal papillary cell cancer tissue (KIRP, p < 0.001; Fig. 2F), lung adenocarcinoma tissue (LUAD, p < 0.001; Fig. 2G), lung squamous cell carcinoma tissue (LUSC, p < 0.001; Fig. 2H) and stomach adenocarcinoma tissue (STAD, p < 0.001; Fig. 2I), compared to each normal tissue. This evidence concerns the gene GSK3B-DT and Familial prostate cancer.