ALB and glomerulosclerosis: In this study, HFD- and STZ-induced DN rats displayed increases in urinary albumin levels, elevated Scr, BUN, TG and TC levels, decreased TP and ALB levels, kidney enlargement, mesangial matrix expansion, GBM thickening, glomerulosclerosis, tubulointerstitial fibrosis and fusion or effacement of foot processes, indicating impaired renal function, disordered lipid metabolism and progression of DN in our animal model.