MT3 and central nervous system cancer: Moreover, data regarding the role of MT3 are still scant and contradictory, some suggesting malignant phenotype-promoting8,9,11,12 or others antitumor effect15 of MT3. As for glioma, induced expression of MT3 as well as MT1 and MT2 following arsenic trioxide treatment on U87-MG glioblastoma cells was demonstrated16, which may be postulated as a potential mechanism for glioma resistance.