PVT1 and leukemia: Collectively, results from CRISPRi and CRISPRa suggest that the PVT1 enhancer, which is marked by the newly identified de novo H3K27ac peak in BETi-resistant leukemia cells, may experience drug-induced remodeling to reactivate MYC transcription after BETi treatment, thereby contributing to BETi resistance in leukemia.