Further flow cytometry and immunoblot analyses revealed that dual inhibition of BET and CDK7 caused cell cycle arrest at the G1 phase (Supplementary Fig. 3c) and enhanced apoptosis in both human leukemia cell lines (K562 and Jurkat, Fig. 2d and Supplementary Fig. 3d) and murine BETi-resistant AF9 AML cells (Fig. 2e and Supplementary Fig. 3e). Here, DNER is linked to acute myeloid leukemia.