Interestingly, we observed BRD4 enrichment at the BENC enhancer regions, but not at the PVT1 locus, in both parental and BETi-resistant AF9 AML cells, suggesting that PVT1 enhancer might be independent on BRD4 binding and take control over MYC re-expression after acquisition of BETi resistance (Fig. 5c). This evidence concerns the gene MYC and acute myeloid leukemia.