Three members of a cullin-RING ubiquitin ligase complex also scored, CUL5 (ascending rank 4, Z-score −9.79), RNF7 (ascending rank 5, Z-score −8.89), and UBE2F (ascending rank 6, Z-score −8.01), which are themselves well-correlated in DepMap and were recently identified as modulators of sensitivity to MCL1 inhibitors in lung cancer cells41. The gene discussed is RNF7; the disease is lung cancer.