Besides, ALKBH5-mediated demethylation of NANOG transcripts mediates breast cancer stem cell enrichment in the hypoxic tumor microenvironment, and higher stability of TFEB mRNA in cardiomyocytes with fewer m6A modifications due to ALKBH5 reverses H/R-mediated TFEB mRNA degradation, and protects cardiomyocytes from apoptosis34,44. This evidence concerns the gene HR and breast carcinoma.