We also found both RASSF2 mRNA (Fig. 1b) and protein (Fig. 1c) expression to be drastically downregulated (~10–50 fold) specifically in t(8;21) AML cell lines relative to non-t(8;21) AML cell lines and healthy human hematopoietic CD34+ cells. The gene discussed is RASSF2; the disease is acute myeloid leukemia.