AKT1 and acute myeloid leukemia: Indeed, differential expression analysis and subsequent GO enrichment revealed the top-two most significantly e cellular processes in t(8;21) AML patients (relative to the RASSF2-high cohort) to be signatures of phagocytosis and leukocyte migration (Fig. 7a, b), which are both well-established to be dependent on Rac GTPases49,50.