Remarkably, gene-set enrichment analysis (GSEA)37 revealed RASSF2 knockdown to cause loss of a gene expression signature specifically associated with AML patients harboring MLL rearrangements38, and gain of a gene expression signature defined by expression of the t(8;21) oncofusion protein RUNX1-ETO39 (Fig. 2c). Here, RASSF2 is linked to acute myeloid leukemia.