Based on the marked RUNX1-ETO-dependent transcriptional repression of RASSF2 (Fig. 1), we hypothesized that comparing gene expression between t(8;21) AML patients and patients with high RASSF2 transcript expression (RASSF2-high) would reveal underlying differences in cellular biology and signal transduction pathways. Here, RUNX1 is linked to acute myeloid leukemia.