Although to confirm the clinical relevance of the findings of this study and the molecular mechanism of FARP1, we must analyze more samples and in vivo experiments, our findings suggest that FARP1 may represent a crucial marker to predict the prognosis of patients with gastric cancer and that the integrin αvβ5-FARP1-CDC42 pathway may serve as a target for molecular therapy in these patients. Here, CDC42 is linked to gastric cancer.