TELO2 and plasma cell myeloma: Another study showed that, in response to growth factor deprivation, Fbxo9-mediated ubiquitination of telomere maintenance 2 (Tel2) and Tel2 interacting protein 1 (Tti1) inactivated mTORC1, but activated the PI(3)K/TORC2/Akt pathway to promote survival in multiple myeloma (23).