ALDOA and PAF1 have recently been described as oncogenes in PDAC (Dey et al. 2014; Vaz et al. 2014; Ji et al. 2016; Nimmakayala et al. 2018), whereas ENO1, RALGDS, TRIP10, and FLNA are known to mediate pancreatic cancer cell proliferation, survival and migration (Chien and White 2003; Li et al. 2009; Mihaljevic et al. 2010; Hsu et al. 2011; Zhou et al. 2011; Capello et al. 2016). Here, ENO1 is linked to familial pancreatic carcinoma.