Depletion of replication-associated proteins such as cohesin (SMC1, SMC3, and RAD21), cohesin-associated factors (ESCO1 and ESCO2), core replication machinery (MCM2/3/6 helicases), and topoisomerases (TOP2B and TOP3A) increases sensitivity to PARP inhibition, as shown in colon and breast cancer cell lines (McLellan et al. 2012; Bajrami et al. 2014). The gene discussed is PARP1; the disease is breast cancer.