BRD4 inhibition induces HR deficiency independent of the BRCA status by impairing CTIP, BRCA1, and RAD51 expression, inducing DNA damage and eventually resulting in mitotic catastrophe in various cancer cell lines and PDX models (Karakashev et al. 2017; Yang et al. 2017; Sun et al. 2018). This evidence concerns the gene RAD51 and cancer.