TP53 and cancer: Mutations in tumor suppressor genes such as the cell cycle checkpoint gene TP53 are common across different cancer types and allow cancer cells to escape senescence or apoptosis and continue proliferating in the presence of DNA damage (The Cancer Genome Atlas Research Network 2011; Kandoth et al. 2013; Nik-Zainal et al. 2016; Robinson et al. 2017; Hafner et al. 2019).