BRCA1 and ovarian carcinoma: In addition to being directly inactivated by mutation, BRCA1 and RAD51C were also found to be down-regulated through promoter hypermethylation in breast and ovarian cancer (Chiang et al. 2006; The Cancer Genome Atlas Research Network 2011; Lips et al. 2013; Timms et al. 2014; Polak et al. 2017; Bernards et al. 2018; Castroviejo-Bermejo et al. 2018; Kondrashova et al. 2018).