BRCA1 and prostate carcinoma: Since then, many examples of secondary mutations in BRCA1/2, as well as RAD51C, RAD51D, and PALB2, that genetically revert the mutation and restore functional full-length protein have been reported in breast, ovarian, pancreatic, and prostate carcinoma (Sakai et al. 2008; Norquist et al. 2011; Barber et al. 2013; Patch et al. 2015; Christie et al. 2017; Goodall et al. 2017; Kondrashova et al. 2017; Lheureux et al. 2017a; Pishvaian et al. 2017; Quigley et al. 2017; Weigelt et al. 2017; Lin et al. 2019).