Depletion of the HR proteins BRCA1/2, PALB2, ABRAXAS, and BARD1 in MCF7 breast cancer cells was shown to elicit synthetic lethal interactions with PARG depletion or PARG inhibition (with gallotannin or PDD00017273) (Fathers et al. 2012; Gravells et al. 2017). The gene discussed is BRCA1; the disease is breast cancer.