Still, in liver mitochondria of NAFLD patients, methylation of mitochondria encoded NADH dehydrogenase 6 was higher in NASH patients when compared to hepatic steatosis patients [166], suggesting a role of epigenetic alterations not only on nuclear DNA, but also on mitochondrial DNA in the development and progression of NAFLD. Here, MT-ND6 is linked to metabolic dysfunction-associated steatohepatitis.