Kinetic studies showed that the relative expression of CD3ζ remained unchanged in CD4+ and CD8+ T cells during the first 6 months after Eg-PSC infection, and the decline occurred at 9 and 12 months in the infected group compared to the control group (F(3, 12) = 94.88, P < 0.001 and F(3, 12) = 75.54, P < 0.001, respectively) (Fig. 3). This evidence concerns the gene CD4 and infection.