Low levels of ANG II, a potent vasoconstrictor, are associated with increased mortality in severe sepsis [17], vasodilatory shock [18], and acute respiratory distress syndrome [19], all of which are conditions with endothelial injury, decreased endothelium-bound ACE activity, and decreased capacity to convert ANG I to ANG II [18–20]. This evidence concerns the gene AGT and acute respiratory distress syndrome.