HMGA2 and cancer: P53-induced miRNAs played a key role in tumor proliferation, metastasis, and angiogenesis by regulating EMT during the initiation and development of cancer; for example, P53-induced miR-1249 might suppress colorectal cancer (CRC) growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2, in addition to regulating the Akt/mTOR pathway and EMT processes [19].