Grade 3 or more severe non-hematological toxicities included grade 3 aspartate aminotransferase/ alanine aminotransferase increase in two patients, grade 3 hypertension in 1, grade 3 protein urea in 1, life-threatening pulmonary embolism in 1, and interstitial pneumonia in 1. The gene discussed is GPT; the disease is Hypertension.