Genetic and pharmacological inhibition of mechanistic target of rapamycin (mTOR) abrogates low folate-activated AKT-mTOR-HIF1-FOXO3a signaling and stemness-associated sonic hedgehog pathway activity, reverses the Warburg metabolic switch, and diminishes invasiveness of non-small cell lung cancer cells. This evidence concerns the gene MTOR and non-small cell lung carcinoma.