Therefore, the aim of the present study was to comprehensively map the distribution of OT and OTR in the male rat brain in order to provide an qualitative overview of their localization in fibres and cells to add to the discussion of migraine/headache pathogenesis in general and to compare with their localization with that of calcitonin gene-related peptide (CGRP) and CGRP receptors in the brain [25]. Here, OXTR is linked to Headache.