BAX and Alzheimer disease: It had also been found that osthole (12.5 mg/kg and 25 mg/kg) regulated the expression of apoptosis-related proteins Bcl-2 and Bax in hippocampus of AD rats, increased the ratio of Bcl-2/Bax, and had anti-apoptotic and protective effects on the hippocampal neurons, which may have a role in improving learning and memory impairment.