CYP7A1 and fatty liver disease: Osthole (10, 20, and 40 mg/kg) was effective against fatty liver by suppressing hepatic sterol regulatory element-binding protein-1c/2 mRNA expressions and modulating the sterol regulatory element-binding protein-1c/2-mediated target gene expression such as fatty acid synthase, cholesterol 7α-hydroxylase, and low-density lipoprotein [116].