BAK1 and colonic neoplasm: When it comes to lower digestive tract cancers such as colon cancer, CMC (120–200 μg/mL) showed cytotoxic effects and induced apoptosis in HCT116 colon cancer cells, it also attenuated mitochondria-related apoptotic proteins which included Bcl-2-associated X protein (Bax) and Bcl-2-homologous antagonist killer (Bak) in a dose-dependent manner [195].