It is observed that when the estradiol 2 level in serum was in a certain amount, osthole (10–20 mg/kg and 10 mg/kg) treated hyperlipidemia and an ovariectomized model could exhibit lower levels of lipoprotein lipase, hepatic lipase, very low-density lipoprotein, chylomicron, and triglyceride [74]. This evidence concerns the gene LPL and hyperlipidemia.