It is also found that osthole (25, 50, and 100 mg/kg) could impede cerebral infarction, hippocampus neuronal lesion, and apoptosis created by middle cerebral artery occlusion/reperfusion (MCAO/R) model via initiating Notch 1 signaling pathway in a dose-dependent manner in vivo. Here, NOTCH1 is linked to cerebral infarction.