Nine patients carried pathogenetic or likely patogenetic variants in ALS/HMN genes (4.2%), 18 subjects carried heterozygous Class-3 variant in autosomal dominant or X-linked ALS genes (8.4%), and 12 patients (5.6%) had heterozygous variants in FTD/HMN-HSP genes. This evidence concerns the gene HSP90B2P and amyotrophic lateral sclerosis.