TP53 and neoplasm: Although the underlying reasons for this lack of CLytA-DAAO effect on non-tumor cells remain unknown, it may be due to the fact that non-tumor cells are not in constant division and their hereditary material is less exposed to the effect of ROS [51] and also, unlike most tumor cell lines, have a TP53 wild type that protects them from the genomic instability generated by ROS [52].