The increase in the concentration of 5-oxo-ETE (in patients who reduce their body mass less than 7%) acts as a chemoattractant and eosinophil activator [39] and can be considered as a negative phenomenon because the OXE receptor for this derivative shows a strong expression on the surface of hepatocytes, making them susceptible to inflammation that leads to NAFLD [39]. The gene discussed is OXER1; the disease is metabolic dysfunction-associated steatotic liver disease.