TP53 and central nervous system cancer: Menyanthes trifoliate root extracts containing terpenoids and polyphenols including SyA led to induction of apoptosis mediated via G2/M phase cell cycle arrest and alterations in the expression of Bax, Bcl-2, cas-3 nad p53 as well as the decrease in the mitochondrial membrane potential in IV glioma cells [49].