As mentioned earlier, laser acupuncture has previously been shown to exert anti-inflammatory effects and to promote wound healing, thus alleviating acute or chronic pain.[4,5] A possible mechanism underlying the produced analgesia is suppression of inducible nitric oxide synthase and microglial p-p38, which are cytokines associated with inflammation.[5] To our knowledge, no previous documentation of laser acupuncture or traditional acupuncture applied for coccyx fracture or coccydynia exists. The gene discussed is NOS2; the disease is bone fracture.