In this study, we characterized the immune cell infiltration landscapes in low-risk and high-risk ccRCC patients, and correlated our IRG signature with the expression of T-cell markers, i.e. CD4 and CD8A, and immune checkpoint genes including PD-1, PD-L1, PD-L2, CTLA-4, LAG3 [43], and CD47 [44]. Here, CD4 is linked to nonpapillary renal cell carcinoma.