PPP1R15A and proteostasis deficiencies: However, GBZ also binds to the regulatory subunit of protein phosphatase 1, PPP1R15A, disrupting the stress-induced dephosphorylation of the α subunit of the translation initiation factor 2 (eIF2α), which protects against the detrimental accumulation of misfolded proteins in the endoplasmic reticulum [72] and has been proven effective in animal models that mimic misfolding protein diseases such as multiple sclerosis [73].