CD4 and cancer: As well, the BMI>35 cohort had a significantly (P = 0.014) lower proportion of natural killer (NK) cells (i.e., for CD56 bright cells and a trend for CD56 dim cells) and a trend towards higher Tregs (CD4+CD127low/-CD25+FoxP3+ cells) (Fig 6B), suggesting a potentially poorer ability to eradicate cancer cells.