These genes were also involved in pathways associated with obesity like regulation of lipolysis in adipocytes, adipogenesis, adipocytokine signaling pathway, renin-angiotensin system, signaling by leptin, toll-like receptor pathway, PI3K-Akt signaling pathway, ras signaling pathway, cytokine signaling in immune system insulin pathway, glucocorticoid receptor regulatory network and NF-kappa B signaling pathway (Table 4). The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.